Nordic Guidance on Diagnosing Inherited Platelet Disorders (IPD)

Authors

Affiliations

Emma Josefsson, Writing – Original Draft

Sahlgrenska University hospital, Gothenburg, Sweden

Riittaa Lassila, Writing – Original Draft

Helsinki University hospital, Helsinki, Finland

Eva Leinoe, Writing – Original Draft

Copenhagen University hospital, Copenhagen, Denmark

Maria Magnusson, Writing – Original Draft

Karolinska University hospital, Stockholm, Sweden

David Schmidt, Writing – Original Draft

Karolinska University hospital, Stockholm, Sweden

Timea Szanto, Writing – Original Draft

Helsinki University hospital, Helsinki, Finland

Eva Zetterberg, Writing – Original Draft

Skane University hospital, Malmö, Sweden

Carola Henriksson, Writing – Review & Editing

Oslo University hospital, Oslo, Norway

Eva Norström, Writing – Review & Editing

Skane University hospital, Malmö, Sweden

Introduction

Inherited platelet disorders (IPD) are a highly heterogeneous group of bleeding diseases caused by germline mutations in genes expressed in platelet and megakaryocytes. Inherited platelet disorders may be associated with thrombocytopenia and can be divided into subgroups depending on the type of functional abnormality: Disorders of a) adhesion, b) aggregation, c) secretion and d) procoagulant activity. Some IPD are not associated with obvious bleeding symptoms and patients with inherited thrombocytopenia may be identified incidentally during routine investigations that include a complete full blood count.