Appendix B — Table 1

A list of drugs, compounds and dietary components/herbs that can affect platelet function.

Reprinted and modified with permission from Kottke-Marchant and Corcoran (2002) [1] with permission from Archives of Pathology and from Harrison et al and British Committee for Standards in Haematology (2011) from British Journal of Haematology [2].

Cyclo-oxygenase (COX)-1 inhibitors Aspirin, acetylsalicylic acid

COX-2 inhibitors

Non-steroidal anti-inflammatory drugs (NSAIDs) Ibuprofen, indomethacin, naproxen

Inhibitors of Platelet Receptors Abciximab, tirofiban, eptifibatide, ticlopidine, clopidogrel, prasugrel, cangrelor, ticagrelor

Phosphodiesterase Inhibitors Dipyridamole,cilostazole

Anticoagulants Heparinoids, vitamin K antagonists and direct thrombininhibitors

Cardiovascular Agents

𝜷-adrenergic blockers Propranolol

Vasodilators Nitroprusside, nitroglycerin

Diuretics Furosemide

Calcium channel blockers

Antimicrobials

𝜷-lactams Penicillins, cephalosporins Amphotericin (antifungal) Hydroxychloroquine (antimalarial) Nitrofurantoin

Chemotherapeutic agents Asparaginase, plicamycin, vincristine

Psychotropics

Tricyclic antidepressants Imipramine

Phenothiazines Chloropromazine

Antiepileptics Valproate (thrombocytopenia)

Miscellaneous Clofibrate, dextrans, guaifenesin (expectorant)

Food/herbs (at high concentrations) Alcohol, caffeine (methylxanthine), cumin, dong quai, fenugreek, garlic, onion, ginger, ginseng

1.

Kottke-Marchant K, Corcoran G. The Laboratory Diagnosis of Platelet Disorders. Archives of Pathology &Amp; Laboratory Medicine 2002;126:133–46. doi:10.5858/2002-126-0133-tldopd.

2.

Harrison P, Mackie I, Mumford A, Briggs C, Liesner R, Winter M, et al. Guidelines for the laboratory investigation of heritable disorders of platelet function. British Journal of Haematology 2011;155:30–44. doi:10.1111/j.1365-2141.2011.08793.x.