Appendix 2
A list of drugs, compounds and dietary components/herbs that can affect platelet function (reprinted and modified with per-mission from Kottke-Marchant and Corcoran (2002) with permission from Archives of Pathology and Laboratory Medicine in “Harrison et al British Committee for Standards in Haematology. Br J Haematol. 2011 Oct;155(1):30-44”).
| Cyclo-oxygenase (COX)-1 inhibitors |
| Aspirin, acetylsalicylic acid |
| COX-2 inhibitors |
| Non-steroidal anti-inflammatory drugs (NSAIDs) |
| Ibuprofen, idomethacin, naproxen |
| Inhibitors of Platelet Receptors |
| Abciximab, tirofiban, eptifibatide, ticlopidine, clopidogrel, prasugrel, cangrelor, ticagrelor |
| Phosphodiesterase Inhibitors |
| Dipyridamole,cilostazole |
| Anticoagulants |
| Heparinoids, vitamin K antagonists and direct thrombininhibitors |
| Cardiovascular Agents |
| 𝛃-adrenergic blockers |
| Propanolol |
| Vasodilators |
| Nitroprusside, nitroglycerin |
| Diuretics |
| Furosemide |
| Calcium channel blockers |
| Antimicrobials |
| 𝛃-lactams |
| Penicillins, cephalosporins |
| Amphotericin (antifungal) |
| Hydroxychloroquine (antimalarial) |
| Nitrofurantoin |
| Chemotherapeutic agents |
| Asparaginase, plicamycin, vincristine |
| Psychotropics |
| Tricyclic antidepressants |
| Imipramine |
| Phenothiazines |
| Chloropromazine |
| Antiepileptics |
| Valproate (thrombocytopenia) |
| Miscellaneous |
| Clofibrate, dextrans, guaifenesin (expectorant) |
| Food/Herbs (at high concentrations) |
| Alcohol, caffeine (methylxanthine), cumin, dong quai, fenugreek, garlic, onion, ginger, ginseng |